Synthesis and characterization of novel pyrazinamide analogs of aspirin and salicylic acid

Date of Publication

6-2011

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemicals and Drugs | Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Glenn V. Alea

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Armando M. Guidote, Jr.
Martin C. Ilao

Abstract/Summary

Pyrazinamide (PZA) analogs of salicylic acid (Compounds 5a and 5b) and aspirin (Compounds 6a and 6b) were synthesized and characterized. The synthesis involved the preparation of salicylic acid and aspirin derivatives with varying acyl chains. The precursors were then coupled with 2-pyrazinehydrazide producing the desired PZA analogues. These compounds may exhibit increased potency against pyrazinamide-resistant and susceptible strains of Mycobacterium tuberculosis.

[Hexagonal structure]

NNNNHOROOHOH 5a R = -(CH2)6CH3 5b R = -(CH2)2CH3 NNNNHOROOHOO 6a R = -(CH2)6CH3 6b R = -(CH2)2CH3.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTG005015

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Keywords

Pyrazinamide—Synthesis

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Embargo Period

5-22-2023

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