C-Prenylated flavonoids in Philippine propolis from nests of stingless bee (tetragonula biroi friese)

Date of Publication

2014

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Glenn V. Alea

Defense Panel Member

Alicia M. Aguinaldo
Jaime Raul O. Janairo

Abstract/Summary

The dichloromethane extract of Philippine propolis from nests of Tetragonula biroi Friese, collected in Sorsogon, afforded two C-prenylated flavonoids: the flavanone Propolin H or Macarangaflavanone A (TB-4), and the dihydroxyflavonol Glyasperin A (TB-1), along with six known triterpenes: a mixture of a-amyrin (TB-2a), b-amyrin (TB-2b), and lupeol (TB-2b), and a mixture of urs-12-ene-3-one (TB-6a), olean-12-ene-3-one (TB-6b), and lupenone (TB-6c). The structures TB-4 and TB-1 were elucidated using 1D and 2D NMR spectroscopy. Stereochemistry of TB-4 was determined using CD spectroscopy. This the first report on the isolation of Glyasperin A from propolis. Furthermore, this is the first report on the isolation of secondary metabolites in Philippine propolis.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTG005698

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

1 computer optical disc ; 4 3/4 in.

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