Date of Publication

4-16-2012

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Glenn V. Alea

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Marissa G. Noel
Alicia P. Catabay

Abstract/Summary

Phthalimide derivatives were synthesized using the concept of molecular hybridization or combination of two pharmacophores in one drug. Four new phthalimides were successfully prepared using a single-step condensation reaction between phthalic anhydride and four different sulfonamides. One previously reported phthalimide was also successfully synthesized from phthalic anhydride and isoniazid. IR and 1H NMR spectroscopic and mass spectrometric data verified the identity and structure of the synthesized compounds. There were attempts to prepare three other compounds, however, their structures remain unconfirmed. The antimycobacterial activity of the synthesized phthalimides was evaluated according to CLSI standard procedures using the agar proportion method. One of the four new compounds, 4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)- -(1,3- thiazol-2-yl)benzenesulfonamide, showed significant activity against Mycobacterium tuberculosis H37Rv strain at 0.01 mg/mL, the lowest concentration at which it was tested.

Abstract Format

html

Language

English

Format

Electronic

Electronic File Format

MS WORD

Accession Number

CDTG005107

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

46 leaves : ill. ; 1 computer optical disc

Keywords

Tuberculosis; Hybridization—Molecular aspects; Molecular genetics

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