Isolation, structure elucidation and antimicrobial properties of secondary metabolites from the leaves of Blumea balsamifera Linn. and Pithhecolobium dulce (Roxb.) Benth

Date of Publication

2008

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Member

Marissa G. Noel
Alicia M. Aguinaldo

Abstract/Summary

Ethyl acetate extract of powdered dried Blumea balsamifera Linn. (Sambong) leaves afforded b-carotene (BB3), icthyothereol acetate (BB4), lutein (BB9), and cryptomeridiol (BB12). The dichloromethane extract of air dried leaves of Pithecolobium dulce (Roxb.) Benth. yielded b-carotene (PD1), mixture of polyprenols (PD3), betuladecaprenol and betulaundecaprenol; lutein (PD4) and spinasterol (PD6). The structures of BB4 and BB12 were elucidated by extensive 1D and 2D NMR spectroscopy, while those of BB3/PD1, BB9/PD4, PD3 and PD6 were identified by comparison with literature. Antimicrobial tests indicated that BB4 has moderate activity against the fungi Aspergillus niger, Trichophyton mentagrophytes and Candida albicans. The isolate BB12 indicated low activity against these fungi. Both compounds expressed no activity against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, and Escherichia coli.

Abstract Format

html

Language

English

Format

Print

Accession Number

TG04570

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Keywords

Anti-infective agents; Microbial metabolites; Blumea balsamifera Linn; Pithhecolobium dulce

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