Date of Publication
2006
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Consolacion Y. Ragasa
Defense Panel Chair
Jaime Raul O. Janairo
Defense Panel Member
Glenn V. Alea
Alicia M. Aguinaldo
Gerardo D. Janairo
Abstract/Summary
The dichloromethane extract of the air-dried seeds of Nephelium lappaceum Linn. var. lappaceum afforded two new diastereomeric monoterpene lactones lappaceolide A and B, and the known butenolide siphonodin [4-(hydroxymethyl)-2(5H)-furanone], by column chromatography. Their structures were elucidated by extensive 1D and 2D NMR spectral interpretation, and characterized by MS, UV and IR spectroscopy.
The antimicrobial activity test using the agar cup method showed that the new monoterpenes were both moderately active against Candida albicans and slightly active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Trichophyton mentagrophytes and Aspergillus niger. However, they were relatively inactive against the bacteria Bacillus subtilis.
The new secondary metabolites represent a novel tricyclic monoterpenoid skeleton. This is also the first report that siphonodin was identified from the plant.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
CDTG004352
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
xviii, 201 leaves ; illustrations ; 28 cm. ; +1 computer disc
Keywords
Rambutan (Nephelium lappaceum); Seeds
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Recommended Citation
De Luna, R. D. (2006). Novel monoterpene lactones from the seeds of Nephelium lappaceum Linn. var. lappaceum (Sapindaceae). Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/3544
