Date of Publication
2008
Document Type
Master's Thesis
Degree Name
Master of Science in Information Technology
Subject Categories
Computer Sciences
College
College of Computer Studies
Department/Unit
Information Technology
Thesis Adviser
Caslon Chua
Defense Panel Chair
Ethel C. Ong
Defense Panel Member
Teresita Limoanco
Merlin Teodosia C. Suarez
Abstract/Summary
Molecular biologists at the Philippine Nuclear Research Institute (PNRI) design synthetic peptide vaccines for infectious diseases such as anthrax, simplex herpes, rabies, and papilloma viruses. They obtained the protein sequence of the corresponding viruses from the World Wide Web using a series of computer programs to formulate the constituents of candidate vaccines, and manually analyzing these virtual vaccines for physical stability. This process is tedious, time consuming, and prone to human errors. Hence, this research designed and created a prototype tool that automates this process. In the development of the tool, the processes were carefully studied. Interviews of the molecular biologists of PNRI were conducted. Screen designs were shown to the molecular biologists and were enhanced until they were accepted. Moreover, the tool was created with a database for molecular biologists to easily keep track of the inputs and outputs of the tool. That is, they could view the previous data, as well as export them to Microsoft Excel worksheet. The tools output is 100% accurate. It was verified through comparing the tools output with manual outputs. In addition, the tool is efficient to use for it reduces the average eleven (11) hours manual processing time to an average of three (3) minutes in using the tool. Furthermore, in using the tool, it could formulate the constituents of the synthetic peptide vaccine to approximately 8640 designs per year.
Abstract Format
html
Language
English
Format
Accession Number
TG04260
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
123 leaves ; 28 cm. + 1 computer optical disc.
Keywords
Philippine Nuclear Research Institute; Synthetic vaccines; Peptides; Vaccines; Medicine
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Recommended Citation
Teo, J. A. (2008). A prototype tool to formulate the constituents of a synthetic peptide vaccine. Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/3455