Date of Publication
11-2000
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Consolacion Y. Ragasa
Defense Panel Chair
Jaime Raul O. Janairo
Defense Panel Member
Glenn V. Alea
Alicia M. Aguinaldo
Abstract/Summary
The chloroform extract of the air dried leaves of Vitex negundo (Linn.) afforded vitexilactone (D2) and casticin (D1), by silica gel column chromatography. Their structures were elucidated by 1D and 2D NMR, IR and UV spectroscopy and confirmed with those reported in the literature. The isolates D2 and D1, reduced the micronucleated polychromatic erythrocytes (MPE) induced by Mitomycin C by 62 % and 83 %, respectively. Thus, the compounds are antimutagens. The antimicrobial activity test showed that the compounds have moderate activity against the fungi: Candidia albicans and Aspergillus niger and slight activity against bacteria: Staphyllococcus aureus and Pseudomonas aeruginosa, but inactive against Eschirichia coli and Bacillus subtillis.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
TG03110
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
x, 147 leaves, 28 cm.
Keywords
Microbial sensitivity tests; Antimutagens; Medicinal plants; Herbals; Extraction (Chemistry)
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Recommended Citation
Morales, E. (2000). Antimicrobial and antimutagenic compounds from Vitex negundo (Linn.). Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/2496
