A new oxetane derivative from Gliricidia sepium (Jacq.) and an antimicrobial and an antimutagenic anthraquinone from Cassia alata (Linn.)
Date of Publication
1999
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Medicinal-Pharmaceutical Chemistry | Organic Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Dr. Consolacion Y. Ragasa
Defense Panel Chair
Dr. Jaime Raul Janairo
Defense Panel Member
Dr. Glenn Alea
Marissa Noel
Abstract/Summary
Two Philippine medicinal plants: Gliricidia sepium and Cassia alata are studied for their secondary metabolites. The chloroform extract of Gliricidia sepium afforded a new oxetane derivative whose structure was elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Cassia alata leaves afforded 1,8-dihydroxy-3-hydroxymethyl-anthraquinone. Its structure was elucidated by extensive 1D and 2D NMR, IR and UV spectroscopy and mass spectrometry. It was found active against Bacillus subtilis with an activity index of 1.8 which is higher than the standard antibiotic chloramphenicol. It reduced the number of micronucleated polychromatic etythrocytes induced by Mitomycin C by 71 percent. Thus, it is an antimutagen.
Abstract Format
html
Language
English
Format
Accession Number
TG02881
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
130 leaves
Keywords
Medicinal plants; Chemistry; Organic; Plants; Useful; Gliricidia sepium; Trees; Antimutagens; Anti-infective agents; Extraction (Chemistry)
Recommended Citation
Hofilena, J. G. (1999). A new oxetane derivative from Gliricidia sepium (Jacq.) and an antimicrobial and an antimutagenic anthraquinone from Cassia alata (Linn.). Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/1985
