Date of Publication

4-1998

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Anamy Ma. C. Paano

Defense Panel Chair

Eric Camilo R. Punzalan

Defense Panel Member

Gerardo C. Janairo
Nancy Lazaro Llanos

Abstract/Summary

Pure and semi-pure isolates were obtained from Entada phaseoloides, Amorphophallus campanulatus, and Polyporus sp. Graded extraction and a series of chromatographic separation of Entada phaseoloides afforded pure isolates EP2B2A, EP3A4A and EP1A1 identified as chondrillsterol (1), spinasterol (2) and a fatty acid or its derivative respectively.Two pure isolates, NU3C1 and NU1A, from the alcoholic extract of Polyporus sp. were also obtained. NU3C1 was identified as stellasterol (3) which has been previously isolated from other Polyporus sp. and NU1A was tentatively identified as an oxygenated sterol (4).A similar skeletal structure was likewise obtained from the alcoholic extract of Amorphophallus campanulatus however C-3 is not in the oxidized form.Analgesic test done on the crude extracts and selected fractions of Entada phaseoloides and Amorphophallus campanulatus showed that they have high potential analgesic property even higher than that of the standard mefenamic acid (EP3 = 59 percent, AC=65 percent, mefenamic acid=55 percent). Polyporus sp. on the other hand showed very high antifungal property particularly against Trichophyton mentagrophytes, the microorganism which causes many types of ring worm. Isolate NU1A was found to have less intense activity against Trichophyton mentagrophytes (A1=1.5 A1 of Clotrimazole=3.0).

Abstract Format

html

Language

English

Format

Electronic

Accession Number

TG02773

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

[x], 93 leaves

Keywords

Antibiotics--Testing; Analgesics; Microbial sensitivity tests; Plants, Useful; Extraction (Chemistry)

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