Date of Publication

4-1998

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Jaime Raul O. Janairo
Marissa G. Noel

Abstract/Summary

Two compounds: N-isobutyl-6-(2-thiophenyl)-2-4-hexadienamide and entkaurane-3,16-diol were isolated from chloroform extract of the leaves of Chrysanthemum coronarium. Their structures were elucidated by extensive ID and 2D NMR spectroscopy and mass spectrometry. The first compound was found to reduce the number of micronucleated polychromatic erythrocyte induced by mitomycin C by 66.5 percent at a dosage of 8 mg/kg. Thus, it is an antimutagen. Both compounds are specifically active against the fungal microorganisms, C. albicans and T. mentagrophytes.For bacterial organism, the first compound was found to be active against B. subtilis and P. aeruginosa, and inactive against S. aureus and E. coli. The second compound was found active against B. subtilis and S. aureus, and inactive against P. aeruginosa and E. coli.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

TG02767

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

x, 86 leaves

Keywords

Plant bioactive compounds; Chemical reactions; Derivatization; Extraction (Chemistry); Diterpenes; Chrysanthemums; Plant bioassay

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