Date of Publication

1-1998

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Jaime Raul O. Janairo
Marissa G. Noel

Abstract/Summary

The chloroform extract of the matured seeds of Swietenia macrophylla afforded swietenolide and a mixture of triglycerides. The structure of swietenolide was elucidated by extensive 1D and 2D NMR spectroscopy and was confirmed by acetylation. The triglyceride was characterized by 1D and 2D NMR and 1R spectroscopy. Swietenoloide and its derivatives as well as the triglyceride were found to inhibit the growth of T. mentagrophytes, but were inactive against E. coli, S. aureus and C. albicans. Both swietenolide and the mixture of triglycerides were found to reduce the number of micronucleated polychromatic erythrocytes (MPCE) induced by Mitomycin C by 57 percent and 21.33 percent, respectively.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

TG02685

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

[iv], 90 leaves

Keywords

Mahogany; Seeds; Triglycerides; Terpenes; Plants--Composition; Extracts

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