Alkaloids and triterpenes from Catharanthus roseus (Linn.) Don
Date of Publication
1997
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Dr. Consolacion Y. Ragasa
Defense Panel Chair
Gerardo C. Janairo
Defense Panel Member
Jaime Raul O. Janairo
Marissa G. Noel
Abstract/Summary
Chloroform extraction of the leaves of Catharanthus roseus (Linn.) Don with lead acetate treatment afforded two alkaloids: perivine I subscript 1 and vindoline I subscript 3 and a triterpene: ursolic acid I subscript 11. The acid-base alkaloidal extraction afforded vindoline I subscript 3 two triterpenes: squalene I subscript 26 and oleanolic acid I subscript 23 and a hydrocarbon tetracosane I subscript 12. The structures of the alkaloids were elucidated using UV, IR, 1D and 2D homonuclear and heteronuclear nmr spectroscopy. Only I subscript 1 was characterized using mass spectrometry. The triterpenes and the hydrocarbon were elucidated using superscript 1 H-NMR. Vindoline I subscript 3 did not inhibit the growth of - Pseudomonas aerugenosa, Saccharomyces cerevisiae, Candida albicans, Escherichia coli, Staphylococcus aureus and Bacillus subtilis but showed a significant antimutagenic activity. The data gathered from the two extraction processes are not conclusive enough to determine which procedure works best. Seasonal and geographical differences affect the production of secondary metabolites.
Abstract Format
html
Language
English
Format
Accession Number
TG02660
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
133 leaves
Keywords
Alkaloids; Terpenes -- Spectra; Solution (Chemistry); Plants; Useful; Medicinal plants; Biological assay
Recommended Citation
Inte, V. L. (1997). Alkaloids and triterpenes from Catharanthus roseus (Linn.) Don. Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/1833