Alkaloids and triterpenes from Catharanthus roseus (Linn.) Don

Date of Publication

1997

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Dr. Consolacion Y. Ragasa

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Jaime Raul O. Janairo
Marissa G. Noel

Abstract/Summary

Chloroform extraction of the leaves of Catharanthus roseus (Linn.) Don with lead acetate treatment afforded two alkaloids: perivine I subscript 1 and vindoline I subscript 3 and a triterpene: ursolic acid I subscript 11. The acid-base alkaloidal extraction afforded vindoline I subscript 3 two triterpenes: squalene I subscript 26 and oleanolic acid I subscript 23 and a hydrocarbon tetracosane I subscript 12. The structures of the alkaloids were elucidated using UV, IR, 1D and 2D homonuclear and heteronuclear nmr spectroscopy. Only I subscript 1 was characterized using mass spectrometry. The triterpenes and the hydrocarbon were elucidated using superscript 1 H-NMR. Vindoline I subscript 3 did not inhibit the growth of - Pseudomonas aerugenosa, Saccharomyces cerevisiae, Candida albicans, Escherichia coli, Staphylococcus aureus and Bacillus subtilis but showed a significant antimutagenic activity. The data gathered from the two extraction processes are not conclusive enough to determine which procedure works best. Seasonal and geographical differences affect the production of secondary metabolites.

Abstract Format

html

Language

English

Format

Print

Accession Number

TG02660

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

133 leaves

Keywords

Alkaloids; Terpenes -- Spectra; Solution (Chemistry); Plants; Useful; Medicinal plants; Biological assay

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