Bioactive furanocoumarin derivatives and a sesquiterpene lactone from Ficus pumila
Date of Publication
1997
Document Type
Master's Thesis
Degree Name
Master of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Dr. Consolacion Y. Ragasa
Defense Panel Chair
Gerardo Janairo
Defense Panel Member
Martin Ilao
Marissa Noel
Abstract/Summary
Ficus pumila afforded two known furanocoumarin derivatives: bergapten and oxypeucedanin hydrate and a sesquiterpene lactone: a tamaulipin isomer. The structures of the furanocoumarin derivatives were elucidated using 1H-nmr, 13 C-nmr, DEPT, and 2D CH heteronuclear correlations: CHSHF and HMBC. The sesquiterpene lactone was characterized using 1H-nmr, 13C-nmr, COSY, NOESY and mass spectrometry. Bergapten showed inhibition against S. typhi, S. aureus and E. coli while oxypeucedanin hydrate was active only with S. typhi. Both furanocoumarins have negative activities against T. mentagrophytes, C. albicans, and M. pleie. Results of the Micronuleus test showed 44 percent and 74 percent reduction in micronucleated polychromatic erythrocytes with bergapten and oxypeucedanin hydrate, respectively.
Abstract Format
html
Language
English
Format
Accession Number
TG02604
Shelf Location
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
Physical Description
131 leaves
Keywords
Medicinal plants; Ficus (Plants); Terpenes; Coumarins; Lactones; Microbial sensitivity tests
Recommended Citation
Juan, E. S. (1997). Bioactive furanocoumarin derivatives and a sesquiterpene lactone from Ficus pumila. Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/1796
