Date of Publication

5-13-1997

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Marissa G. Noel
Eric R. Punzalan

Abstract/Summary

Malachra fasciata afforded loliolide, a glycerol derivative and stigmasterol. The structures of loliolide and the glycerol derivative were elucidated using 1H-NMR, 13C-NMR, DEPT, HMQC and HMBC. Stigmasterol was identified by comparison of its 1H-NMR spectral data with those found in the literature.Five compounds were re-isolated from E. scaber: stigmasterol, lupeol lupeol acetate, deoxyelephantopin and isodeoxyelephantopin. The compounds were identified by comparing their melting points and Rf values against those found in the literature.Results of Micronucleus test showed 64.4 percent, 79.09 percent, 78.6 percent, 80.7 percent, 81.0 percent and 79.3 percent reduction in micronucleated polychromatic erythrocytes induced by Mitomycin C when loliolide, stigmasterol, lupeol acetate, lupeol, deoxyelephantopin and isodeoxyelephantopin, respectively were administered to mice of the Swiss strain. These indicate that all samples tested are antimutagens.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

TG02597

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

94 leaves

Keywords

Antimutagens; Terpenes; Sterols; Chloroform; Extracts; Herbals; Medicinal plants; Plant metabolites

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