Date of Publication

6-1992

Document Type

Master's Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Gerardo Janairo
Anamy Paano

Defense Panel Chair

Wyona Patalinghug

Defense Panel Member

Christine Ngo
Consolacion Ragasa

Abstract/Summary

A new optically active cembrane diterpene (m.p. 215 - 216'C) was isolated by vacuum liquid chromatography from the dichloromethane extract of a Philippine soft coral Sinularia Flexibilis. Microanalysis coupled with n.m.r. spectral data established a molecular formula of C20H32O7.A cembrane-type skeleton was derived based on the IR, UV, and n.m.r. data and from other information obtained from the literature. The bicyclic variation of the cembrane skeleton was necessary to satisfy the calculated index of hydrogen deficiency.The 13C-n.m.r. spectrum revealed a ketone and a lactone carbonyl groups, and the aliphatic as well as the olefinic carbon atoms. The 1H-n.m.r. spectrum indicated aliphatic, olefinic as well as hydroxy protons. The ketone, lactone, hydroxy and olefinic functionalities were further indicated in the IR spectrum. One conjugated system was deduced from the UV spectrum.A complete assignment of the 1H-n.m.r. and 13C-n.m.r. was made possible from the C-H correlation and COSY spectrum.

Abstract Format

html

Language

English

Format

Print

Accession Number

TG01999

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

47 leaves

Keywords

Alcyonacea; Diterpenes

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