Effect of Hordeum vulgare, Moringa oleifera and Vitex negundo extracts on the hippocampus and memory of the Mus musculus

Date of Publication

2016

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Biology

College

College of Science

Department/Unit

Biology

Thesis Adviser

Michel Ples

Defense Panel Member

Mary Jane C. Flores

Abstract/Summary

Herbal medicine such as Hordeum vulgare, Moringa oleifera and Vitex negundo are widely recognized around the world as dietary supplements, remedy for ailments and bodily sustenance. Moreover, studies have shown that intake these herbal medicines can have an effect in the memory retention in mice, however, no further studies have been conducted in comparing between Lagundi, Moringa and Barley and their optimal dosages on treatments for the effect of memory in mice. In this study, the mice were orally gavaged with three specific dosages (250 mg/kg, 500 mg/kg and 750 mg/kg) of each herbal supplements, Barley, Moringa and Lagundi. The mice were then subjected to a 2- day water maze test and the neurological effects such as hippocampal reduction and degeneration were analyzed histologically. The result showed that in the Water Maze Test, all dosages of the different treatments showed no significant difference with the control group, therefore memory improvement or impairment was not shown during the maze test. In the histological analysis, however, it showed that Barley did not interfere with the hippocampal neurons the cells are within the normal limit and did not undergo cell degeneration. Moringa and Lagundi on the other hand, resulted to neurotropic effects of impaired hippocampal neurons with Lagundi causing more damage than Moringa.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTU017599

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

1 computer disc ; 4 3/4 in.

Keywords

Herbs--Therapeutic use; Barley; Moringa oleifera; Extracts

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