A comparative study of the level of cholesterol and triglycerides in the serum and liver of obesed mice fed with orlistat and chitosan
Date of Publication
2002
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Chemistry
Subject Categories
Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Nancy Lazaro-Llanos
Defense Panel Chair
Wyona C. Patalinghug
Defense Panel Member
Abstract/Summary
The proficiency of a synthetic drug, Orlistat versus a natural dietary supplement, Chitosan on the lowering of cholesterol levels and Triglyceride levels of the blood serum and liver of obese Swiss mice after three weeks of feeding were compared. Four groups of mice were fed for 6 weeks with diets as follows (1) normal group (no orlistat or chitosan) (2) chitosan group (3) orlistat group (4) both chitosan-orlistat group. After 6 weeks, cholesterol levels and triglyceride levels were determined by absorption spectroscopy. The normal group had the highest level of cholesterol and triglyceride in both the blood serum and liver compared to the other three groups of mice while the chitosan-orlistat group had the lowest. Only the normal group had gained weight and all the groups that had taken the dietary pills had lost weight. The chitosan-orlistat group had the lost the highest amount of weight and the chitosan group had the lowest. Results are in agreement with previous studies.
In summary, a combination of orlistat and chitosan resulted in the greatest decease in weight, liver and serum cholesterol and triglyceride, exhibiting an additive effect compared to the orlistat and chitosan groups.
Abstract Format
html
Language
English
Format
Accession Number
TU17454
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
ix, 68 leaves, illustrations (some color), 28 cm.
Keywords
Cholesterol; Food--Cholesterol content; Serum; Blood cholesterol; Triglycerides
Recommended Citation
Santiago, H. P., & Santiago, M. C. (2002). A comparative study of the level of cholesterol and triglycerides in the serum and liver of obesed mice fed with orlistat and chitosan. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/6476