Antimutagenicity potential of isolates from the Dichloromethane extract of Solanum nigrum
Date of Publication
1997
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Chemistry
College
College of Science
Department/Unit
Chemistry
Thesis Adviser
Consolacion Ragasa
Defense Panel Chair
Gerardo Janairo
Abstract/Summary
The leaves of Solanum nigrum were air dried, ground and soaked in dichloromethane. The dichloromethane extract afforded three isolates which were obtained by repeated gravity column chromatography, and monitored by thin layer chromatography. The three isolates were tested for antimutagenicity potential by the Micronucleus test. Results showed that TLC pure isolate A increased the number of micronucleated polychromatic erythrocytes (MPCE) induced by Mitomycin C by 34.87%. Thus, it is a mutagen. On the other hand, TLC pure isolates B and C reduced the number of MPCE by 11.58% and 67.50% respectively. Thus, both compounds are antimutagens.
Abstract Format
html
Language
English
Format
Accession Number
TU17469
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
[7], 49 leaves : illustrations (some color) ; 28 cm.
Keywords
Antimutagens; Dichloromethane; Methane; Solanum nigrum
Recommended Citation
De Guzman, M., & Yabut, A. (1997). Antimutagenicity potential of isolates from the Dichloromethane extract of Solanum nigrum. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/5921
