Toxicity analysis of a mixture of triterpenes from Makopa [Syzygium samarangense (Blume) Merr. and Perry (Myrtaceae)] on zebrafish (Danio Rerio) embryos

Date of Publication

2010

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Biology | Plant Biology | Toxicology

College

College of Science

Department/Unit

Biology

Thesis Adviser

Dennis D. Raga

Defense Panel Chair

Gliceria B. Ramos

Abstract/Summary

Syzygium samarangense (Blume) Merr. and Perry locally known as Makopa (Tag.), is a popular backyard tree in the Philippines. Folklorically, it has been used to treat fever and diarrhea. In this study, dechorionated zebrafish embryos and embryos with intact chorion were exposed to a mixture of triterpenes 8a-8d at two different time points (24hpf and 36hpf). An effect on mortality was observed in dechorionated treatments at both time points, which suggests that the compounds might have a toxic effect on embryonic tissues and cannot be concluded as so. However, delayed hatching and increased mortality was observed in embryos with intact chorion, suggesting that chorionic integrity was compromised by 8a-8d treatment.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTU019093

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

1 computer disc ; 4 3/4 in.

Keywords

Syzygium--Analysis; Syzygium—Toxicology; Logperch—Spermatozoa—Morphology

Embargo Period

4-18-2021

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