Analgesic property of Atalantia retusa Merr. (Rutaceae) non-polar extract on rats and mice
Date of Publication
2008
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Biology
Subject Categories
Biology
College
College of Science
Department/Unit
Biology
Thesis Adviser
Dennis D. Raga
Abstract/Summary
The continuous search for bioactive compounds capable of effectively inhibiting nociception has directed the study to investigate on the analgesic potential of Atalantia retusa. Male ICR mice (n=9) and Sprague-Dawley rats (n=6) were used to verify antinociception using the somatic and visceral pain models respectively. There was significant (P < 0.001) inhibition of abdominal stretches in mice administered with the median dose (1.437mg/kg BW) of the non-polar extract, which is 55.48% better compared to the positive control (10mg/kg BW). Concomitantly, the non-polar extract have significantly (P < 0.05) inhibited paw licking and biting in the somatic model by 6.05% better compared to the positive control. The current study demonstrated the potential use of A. retusa as an analgesic drug.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
CDTU019033
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
1 computer optical disc ; 4 3/4 in.
Recommended Citation
Ganacias, R. (2008). Analgesic property of Atalantia retusa Merr. (Rutaceae) non-polar extract on rats and mice. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/2457
