The anti-inflammatory capabilities of the kamutmut plant and the mechanism of action

Date of Publication

12-2016

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Biology

College

College of Science

Department/Unit

Biology

Thesis Adviser

Esperanza C. Cabrera

Abstract/Summary

The study determined the anti-inflammatory capabilities of the aqueous leaf, stem, leaf-stem extracts of the kamutmutplant collected from a lahar-rich sacarum grassland in Pampanga.. The anti-inflammatory activities were tested using the carrageenan-induced paw edema assay on ICR mice using dexamethasone as the positive control. The plant extracts in the concentration of 10% w/v caused significant decrease in inflammation when administered 1h, 2h and 2.5h after the induction of inflammation. The % inhibition of the extracts were not significantly different from that of dexamethasone (p>0.05). At the same time, all the plant extracts were found to be non-cytotoxic to the normal human fibroblast cell line HDFn using the Presto BlueTM resazurin assay. Furthermore, all the test extracts inhibited the expression of the pro- inflammatory genes TNFα and IL1βas assayed using qRTPCR (p< 0.05 compared to the positive control of LPS-treated PMA- induced THP1 cells).

Abstract Format

html

Accession Number

CDTU021773

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Keywords

Medicinal plants--Philippines; Anti-inflammatory agents--Philippines; Traditional medicine--Philippines

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Embargo Period

5-26-2025

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