Immunohistochemical detection of S-100 in the spleen of the domestic cat (Felis catus L) (Felidae: Carnivora)

Date of Publication

6-2017

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

Subject Categories

Animal Sciences

College

College of Science

Department/Unit

Biology

Thesis Adviser

Rodel Jonathan S. Vitor II

Abstract/Summary

The spleen of twenty (ten male and ten female) domestic cat (Felis catus L.) were examined by immunohistochemical methods to identify S-100 reactive structures. In all sections of the spleen, S-100 was found in the nerve elements, and in the endothelial cells lining the capsular arteries, trabecular arteries, penicillar arterioles and sheathed capillaries in the red pulp, and splenic arterioles in the white pulp, as well as in the macrophages and reticular cells that formed a sleeve around the penicillar arterioles and sheathed capillaries of the spleen, lymphoid follicles and PALS of the white pulp. On the other hand, it has been found to be negative in the veins in both the stroma and parenchyma. It is hypothesized that S-100 in the endothelial cells of sheathed capillaries is suggestive of its function in regulating the semi-permeability of the blood vessels while the demonstration of S-100 in the nerves may indicate that it is transported from gliocytes secreting it to the target cells. The present findings are basically similar to those in the other domestic animals except for negative findings that have already been mentioned above.

Abstract Format

html

Language

English

Format

Electronic

Accession Number

CDTU021786

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Keywords

Immunohistochemistry; Cats; Spleen

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Embargo Period

5-28-2025

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