A study on the histological effects of piroxicam on the kidney of male Mus musculus (white mice)

Date of Publication

1999

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

Piroxicam is a Nonsteroidal Anti-inflammatory Drug. Different concentrations of piroxicam (2 mg/kg, 4 mg/kg, 6 mg/kg, and 8 mg/kg) were administered with male Mus musculus for two weeks to determine which among these concentrations damaged their kidneys. It was observed that 2 mg/kg and 4 mg/kg bodyweight of piroxicam have caused minor tubular changes and that the Bowman's space was starting to have clearing out on mice kidneys. Those which were treated with 6 mg/kg and 8 mg/kg bodyweight of piroxicam were observed that their glomeruli are dense and compact and relatively clear Bowman's space. In conclusion, glomerular changes were caused by toxic agents that were filtered by glomeruli. These toxic agents may cause leakage of glomerular filtrate through the tubular walls.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU08996

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

23 leaves

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