Understanding the effect of Raphanus sativus extract on the pathogenesis of chronic myeloid leukemia, breast and colon cancer through mathematical modeling
Date of Publication
2016
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Statistics Major in Actuarial Science
Subject Categories
Statistics and Probability
College
College of Science
Department/Unit
Mathematics and Statistics
Abstract/Summary
Chronic myeloid leukemia (CML), breast, and colon cancer are among the most prevalent types of cancer in the Philippines. In most of the cancer cases reported annually, cancer is only detected when it is on its advance stage due to the lack of early detection and limited options of targeted therapies. There are studies that show different effects of Raphanus sativus (radish) extract on different cancer diseases. However, it is still unknown why it has different effects on different cancer diseases. Therefore, understanding disease dynamics would help in improving prognosis and diagnosis. In this study, we propose a mathematical model that would explain the effect of Raphanus sativus extract on the pathogenesis of CML, breast and colon cancer. Since p53 is one of the most extensively studied gene in the field of cancer research and Cyclin D1-CDK complex is one of the more frequently altered cell cycle regulators in cancers, these genes are the focus for the basis of the effectiveness of the drug. Based on our simulations, we have showed that a 99.99%, 99.68%, and 98.96% decrease in the steady-state concentration of p53 are observed in breast cancer, colon cancer, and CML, respectively, after the drug was inserted in the model. Moreover, Cyclin D1-CDK complex's steady-state concentration is decreased by 99.91% in breast cancer, 99.89% in colon cancer, and 98.50% in CML. Hence, the model suggests that Raphanus sativus extract is highly effective on breast cancer followed by colon cancer and CML.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
CDTU021079
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
1 computer disc ; 4 3/4 in.
Keywords
Radishes; Leukemia; Colon (Anatomy)--Cancer; Cancer
Recommended Citation
Edra, J. j., & Talag, K. T. (2016). Understanding the effect of Raphanus sativus extract on the pathogenesis of chronic myeloid leukemia, breast and colon cancer through mathematical modeling. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/14906
Embargo Period
5-11-2021
