EDTA as chelating agent of lead in rabbits

Date of Publication

1996

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

A 75 percent sublethal lead dosage of 202.5 mg/kg body weight was administered intravenously to male rabbits (Oryctolagus cuniculus) for two weeks. Another experimental group also treated with 202.5 mg/kg. of lead was subsequently administered intravenously with 12.5 mg/kg EDTA. This was done to determine whether its mobilization of accumulated lead in tissues would cause a significant decrease of lead level in the organs.Analysis by atomic absorption spectrophotometry showed lead accumulated at its highest concentration in the liver (2.93 ug/g), then in the kidney (2.03 ug/g) and lastly in the lungs (0.919 ug/g). The treated lead group which were subsequently administered with EDTA showed a decrease of lead level in the liver (1.09 ug/g), in the kidney (1.44 ug/g) and lungs (0.240 ug/g). However, the difference of lead concentration in all organs between the lead + EDTA injected rabbits and lead injected rabbits was not significant.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU07365

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

30 leaves

Keywords

Lead--Toxicology; Rabbits; Ethylenediaminetetraacetic acid; Heavy metals; Chelation therapy; x3 EDTA

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