EDTA as chelating agent of lead in rabbits
Date of Publication
1996
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Biology
College
College of Science
Department/Unit
Biology
Abstract/Summary
A 75 percent sublethal lead dosage of 202.5 mg/kg body weight was administered intravenously to male rabbits (Oryctolagus cuniculus) for two weeks. Another experimental group also treated with 202.5 mg/kg. of lead was subsequently administered intravenously with 12.5 mg/kg EDTA. This was done to determine whether its mobilization of accumulated lead in tissues would cause a significant decrease of lead level in the organs.Analysis by atomic absorption spectrophotometry showed lead accumulated at its highest concentration in the liver (2.93 ug/g), then in the kidney (2.03 ug/g) and lastly in the lungs (0.919 ug/g). The treated lead group which were subsequently administered with EDTA showed a decrease of lead level in the liver (1.09 ug/g), in the kidney (1.44 ug/g) and lungs (0.240 ug/g). However, the difference of lead concentration in all organs between the lead + EDTA injected rabbits and lead injected rabbits was not significant.
Abstract Format
html
Language
English
Format
Accession Number
TU07365
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
30 leaves
Keywords
Lead--Toxicology; Rabbits; Ethylenediaminetetraacetic acid; Heavy metals; Chelation therapy; x3 EDTA
Recommended Citation
Modomo, B. T. (1996). EDTA as chelating agent of lead in rabbits. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/1374