Effects of cyclosporin-A on mouse kidney: A histological study

Date of Publication

1995

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biology

College

College of Science

Department/Unit

Biology

Abstract/Summary

Twenty white mice (Mus musculus) were divided into four groups. The first three groups were treated with different doses of Cyclosporin-A (30, 50, 70 mg/kg/day) for 21 days. Treatment were done by mixing the given doses to their regular 5 mg food pellets. The last group served as the control group receiving the same amount of food. Cyclosporin-A effects on the kidney showed historical abnormalities. Generally, cellular edema, tubular swelling, hyalinization and lymphocyte infiltration were observed in the Cyclosporin-A treated kidneys. Increasing concentration of the drug was in parallel with the severity of the damage. Most damage was observed on the last week of treatment.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU06905

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

45 leaves

Keywords

Cyclosporin-A; Mice; Immunosuppressive agents; Peptides; Kidneys; Drugs

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