The analgesic effect of a mixture of Bauerenol, A-Amyrin and B-Amyrin in A 1:1:1 ratio from Ardisia SP. Leaves on ICR mice
Date of Publication
2011
Document Type
Bachelor's Thesis
Degree Name
Bachelor of Science in Biology
College
College of Science
Department/Unit
Biology
Thesis Adviser
Dennis D. Raga
Defense Panel Chair
Jose Santos R. Carandang, VI
Defense Panel Member
Florencia G. Claveria
Noel F. Alfonso
Patricio Elvin D. Cantiller
Abstract/Summary
Ardisia sp. is a genus plants found in tropical and subtropical areas has been known for their phytoparmacheutical compounds with various properties, testing them for helpful bioactivities lead to the discovery of new medicines which help treat millions of people. A mixture of bauerenol, Ü-amyrin, Ý-amyrin in a 1:1:1 ratio was evaluated for analgesic bioactivity. Three bioassays were used: acetic acid writhing assay, hotplate assay and tailflick assay. The hotplate and tailflick assays test the compound’s inhibition of sensitivity to thermally induced pain. Both were performed at two points post administration (30 and 75 minutes). The acetic acid writhing assay tests the compounds inhibition of sensitivity to chemically induced pain. The acetic acid writhing assay is an observation of the test animals for 10 minutes post injection of the acetic acid. The compound did not produce an analgesic effect in the hotplate and tailflick assays which test for thermally induced pain, however, the data collected in the acetic acid writhing assay suggests a possible inhibition of the chemically induced pain.
Abstract Format
html
Language
English
Format
Electronic
Accession Number
CDTU019219
Shelf Location
Archives, The Learning Commons, 12F, Henry Sy Sr. Hall
Physical Description
leaves ; 4 3/4 in.
Recommended Citation
Evangelista, J., Kim, S., & Lo, M. A. (2011). The analgesic effect of a mixture of Bauerenol, A-Amyrin and B-Amyrin in A 1:1:1 ratio from Ardisia SP. Leaves on ICR mice. Retrieved from https://animorepository.dlsu.edu.ph/etd_bachelors/11814