Title

Isolation and purification and characterization of Ciguatera toxins from Thunnus albacares

Date of Publication

2001

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Ferdinand F. Fajardo
Maria Christina Z. Floresca

Abstract/Summary

Ciguatera is a disease caused by ciguatoxins, which accumulates in the flesh and viscera of fishes. Ciguatoxins (CTX) are produced by the unicellular, microscopic, benthic dinoflagellate Gambierdiscus toxicus. These ciguatoxins were isolated and purified from yellow fin tuna, Thunnus albacares, acquired from Masinloc, Zambales and Odiongan, Romblon. High Performance Liquid Chromatography (HPLC) and Electrospray ionization Mass Spectroscopy (ESI-MS) were employed to verify the presence of CTX in the fish samples. Mouse bioassay was performed to determine its toxicity. CTX extracted from Romblon samples showed positive results in mouse bioassay and MS analysis.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU17486

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

vi, 44 leaves : illustrations ; 29 cm.

Keywords

Yellowfin tuna--Philippines; Poisonous fishes--Toxicology--Philippines; Food contamination--Philippines; Food poisoning--Philippines

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