Title

Potential anti-cancer and anti-bacterial activities of Philippine echinoderm extracts

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Journal of Tropical Life Science

Volume

4

Issue

3

First Page

175

Last Page

181

Publication Date

11-2014

Abstract

In high-throughput search for bioactive compounds under resource-limited settings from Philippine echino­derms, the aqueous, methanol, chloroform and hexane extracts of seven Philippine echinoderms namely Holothuria nobilis (sea cucumber), Bohadscia marmorata (sea cucumber), Stichopus chloronatus (sea cucumber), Holothuria axiologa (sea cucumber), Linckia laevigata (starfish), Oreaster nodusus (starfish) and Ophiocoma ochoenleinii (brittle star) were screened for antitumor and antibacterial activity. Antitumor activity was deter­mined using brine shrimp lethality assay while antibacterial assay was performed using turbidimetric method. Both assays utilized 96-well microtiter plates to facilitate speed and ease in screening. The chloroform extract of H. nobilis gave a positive result on antitumor activity while almost all sample extracts showed antibacterial activity against E. coli.

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Disciplines

Biology

Keywords

Echinodermata—Philippines; Echinodermata—Analysis; Antineoplastic agents; Antibacterial agents

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