Title

Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of babesia bigemina and babesia bovis (Phylum Apicomplexa)

College

College of Science

Department/Unit

Biology

Document Type

Article

Source Title

Parasitology

Volume

127

Issue

4

First Page

311

Last Page

315

Publication Date

10-1-2003

Abstract

We evaluated the growth inhibitory efficacy of the imidazole derivatives, clotrimazole (CLT) and ketoconazole (KC), and the herbicide clodinafop- propargyl (CP), in in vitro cultures of Babesia bovis and B. bigemina. Clotrimazole was effective in a dose range of 15 to 60 μM (IC 50:11 and 23.5 μM), followed by KC (50 to 100 μM; IC 50 : 50 and 32 μM) and CP (500 μM; IC50 : 265 and 390 μM). In transmission electron microscopy, extensive damage was observed in the cytoplasm of drug-treated parasites. Combinations of CLT/KC, CLT/CP and CLT/KC/CP acted synergistically in both parasites. In contrast, the combination of KC/CP was exclusively effective in B. bovis, but not in B. bigemina.

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Digitial Object Identifier (DOI)

10.1017/S0031182003003895

Disciplines

Biology

Keywords

Babesiosis in cattle; Babesia bigemina; Ketoconazole; Antifungal agents

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