Title

Chemical constituents and cytotoxicity of the leaves of Dysoxylum gaudichaudianum (A. Juss.) Miq.

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Der Pharma Chemica

Volume

6

Issue

5

First Page

182

Last Page

187

Publication Date

1-1-2014

Abstract

The crude dicloromethane leaf extract of Dysoxylum gaudichaudianum (A. Juss.) Miq. was tested for cytotoxicity against breast cancer (MCF-7) and colon cancer (HT-29) cells and exhibited IC50 values of 7.35 and 13.19 μg/mL, respectively. Chemical investigation of the dichloromethane leaf extract afforded squalene (1), β-sitosterol (2), polyprenols (3) and triglyceride (4). The structures of 1-4 were identified by comparison of their 1H NMR data with those reported in the literature. These compounds are known cytotoxic and anticancer compounds.

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Disciplines

Chemistry

Keywords

Meliaceae--Analysis; Meliaceae—Toxicity testing; Foliar diagnosis

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