Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review
College
College of Science
Department/Unit
Biology
Document Type
Article
Source Title
European Journal of Microbiology and Immunology
Volume
14
Issue
1
First Page
13
Last Page
25
Publication Date
2-2-2024
Abstract
Staphylococcus aureus infections have already presented a substantial public health challenge, encompassing different clinical manifestations, ranging from bacteremia to sepsis and multi-organ failures. Among these infections, methicillin-resistant S. aureus (MRSA) is particularly alarming due to its well-documented resistance to multiple classes of antibiotics, contributing significantly to global mortality rates. Consequently, the urgent need for effective treatment options has prompted a growing interest in exploring phage therapy as a potential non-antibiotic treatment against MRSA infections. Phages represent a class of highly specific bacterial viruses known for their ability to infect certain bacterial strains. This review paper explores the clinical potential of phages as a treatment for MRSA infections due to their low toxicity and auto-dosing capabilities. The paper also discusses the synergistic effect of phage-antibiotic combination (PAC) and the promising results from in vitro and animal model studies, which could lead to extensive human clinical trials. However, clinicians need to establish and adhere to standard protocols governing phage administration and implementation. Prominent clinical trials are needed to develop and advance phage therapy as a non-antibiotic therapy intervention, meeting regulatory guidelines, logistical requirements, and ethical considerations, potentially revolutionizing the treatment of MRSA infections.
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Recommended Citation
Fortaleza, J. G., Ong, C. N., & De Jesus, R. (2024). Efficacy and clinical potential of phage therapy in treating methicillin-resistant Staphylococcus aureus (MRSA) infections: A review. European Journal of Microbiology and Immunology, 14 (1), 13-25. Retrieved from https://animorepository.dlsu.edu.ph/faculty_research/14006
Disciplines
Biology | Immunology and Infectious Disease
Keywords
Staphylococcus aureus; Staphylococcus aureus infections; Bacteriophages; Drug resistance in microorganisms
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