Hepatotoxicity and mutagenicity assessment during chronic in vivo exposure to aqueous extracts from peperomia pellucida

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Anais da Academia Brasileira de Ciências

Volume

94

Issue

2

Publication Date

2022

Abstract

Studies on herbal medicine have exposed some toxic effects on humans. Peperomia pellucida (L.) HBK (P. pellucida) is one of the herbal medicines recommended as an alternative to synthetic medicine for diseases. Studies exist on the pharmacological activities of P. pellucida extracts, but studies on the potential hepatotoxic and mutagenic effects of subchronic administration of P. pellucida aqueous extracts, which is very important knowledge when we venture into alternative medicine, are lacking. In this study, two concentrations (60 mg/kg and 30 mg/kg) of P. pellucida aqueous extracts — decoction and freeze-dried extracts —were administered in vivo to BALB/c mice for nine (9) weeks. Signifi cant differences were observed between the 60 mg/kg freeze- dried extract and the control in terms of mice weight and micronucleus frequency at 7-8 weeks of treatment. Also, no signifi cant differences were found between groups in serum transaminases levels. Generally, there is no suffi cient evidence to show that subchronic exposure to P. pellucida aqueous extracts is hepatotoxic though 60 mg/kg concentration may be mutagenic. This study suggests that although the herbal medicine is safe for prolonged consumption, users are advised to take precautions and moderations of its use due to the possibility of potential mutagenic effects.

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Digitial Object Identifier (DOI)

10.1590/0001-3765202220191255

Disciplines

Chemistry

Keywords

Peperomia; Hepatotoxicology; Mutagenicity testing

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