Title

Chemical constituents of Syzygium samarangense

College

College of Science

Department/Unit

Chemistry

Document Type

Article

Source Title

Der Pharma Chemica

Volume

6

Issue

3

First Page

256

Last Page

260

Publication Date

1-1-2014

Abstract

The dichloromethane extract of the leaves of Syzygium samarangense (Blume) Merr. & Perry afforded 2′,4′- dihydroxy-6′-methoxy-3′-methylchalcone (1), 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethylchalcone (2), 2′-hydroxy- 4′,6′-dimethoxy-3′-methyl chalcone (3), squalene (4), betulin (5), lupeol (6), sitosterol (7), and a mixture of cycloartenyl stearate (8a), lupenyl stearate (8b), β-sitosteryl stearate (8c), and 24-methylenecycloartenyl stearate (8d). The structures of 1-3, 5, 7, and 8a-8d were elucidated by 1D and 2D NMR spectroscopy. Sample 8 was tested for hypoglycemic and antimicrobial potentials. It showed negative hypoglycemic potential and exhibited moderate antifungal activity against C. albicans, low activity against T. mentagrophytes and low antibacterial activity against E. coli, S. aureus and P. aeruginosa. It was inactive against B. subtilis and A. niger.

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Disciplines

Chemistry

Keywords

Syzygium--Analysis

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