Date of Publication
Master of Science in Chemistry
College of Science
Derrick Ethelbhert C. Yu
Defense Panel Chair
Defense Panel Member
Anamy Ma. C. Paano
Maribel G. Nonato
An unprecedented condensation reaction of N-benzylimines was applied to the bioconjugation of lysine residues. A second-generation lysine dendrimer 14 with four ε-amino groups was prepared as the model peptide using solid-supported methods. The dendrimer 14 reacted with N-benzylimine 8 in DMF, which was readily obtained from fumaraldehydic acid methyl ester and benzylamine, to provide the corresponding 1,2 diazetidine derivatives at room temperature. The reaction might proceed through the conjugate addition of the lysine ε-amino groups to the α-β unsaturated ester of 8 followed by the condensation between the two imines. The novel reaction offers a promising “click” reaction for bioconjuation since it does not require any catalysts and proceeds under mild conditions.
Electronic File Format
Archives, The Learning Commons, 12F Henry Sy Sr. Hall
1 computer optical disc, 4 3/4 in.
Imines; Bioconjugates; Condensation
Upload Full Text
Janairo, J. B. (2011). Substrate screening for a novel condensation of imines: New approach towards a "click" type reaction for bioconjugation. Retrieved from https://animorepository.dlsu.edu.ph/etd_masteral/6626