Title

Antifungal flavones from Waltheria americana

Date of Publication

1996

Document Type

Masteral Thesis

Degree Name

Master of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Dr. Consolacion Y. Ragasa

Defense Panel Chair

Gerardo C. Janairo

Defense Panel Member

Jaime Raul Janairo
Marissa Noel

Abstract/Summary

Walteria americana [common name: Barulad (Ilocano), Kanding-kanding (Negros Occidental)] belongs to the family Sterculiaceae. Walteria americana afforded two flavones, 5,2,5,' trihydroxy-3,7,4' trimethoxy flavone and 5,2' dihydroxy-3,7,4',5' tetramethoxyflavone. The structure of the first compound was elucidated by Hydrogen-1-nuclear magnetic resonance (1H-NMR), Carbon-13-nuclear magnetic resonance (13C-NMR), 1H Detected Heteronuclear Multibond (long-range) Shift Correlation (HMBC), Heteronuclear Multiquantum Coherence (HMQC), Nuclear Overhausser Effect Spectroscopy (NOESY), D2O Exchange and Mass Spectrometry. This was further confirmed by Chemwindow 13C shift prediction. The identity of the second isolate was determined by comparison of its 1H-NMR, 13C-NMR and Mass Spectrum with that of the first compound.Both flavones are exclusively very active against the fungal microorganisms, Aspergillus niger, Candida albicans and Trichophyton mentagrophytes but inactive when tested against gram (+) positive and gram (-) negative, Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus.

Abstract Format

html

Language

English

Format

Print

Accession Number

TG02512

Shelf Location

Archives, The Learning Commons, 12F Henry Sy Sr. Hall

Physical Description

74 leaves

Keywords

Antifungal agents; Flavonoids -- Spectra; Microbial sensitivity tests; Solution (Chemistry); Medicinal plants; Sterculiaceae

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