Title

Isolation and antimutagenicity potential of components from the Ethyl Acetate Extracts of Vitex parviflora

Date of Publication

2001

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Chemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Y. Ragasa

Defense Panel Chair

Wyona C. Patalinghug

Abstract/Summary

Six TLC pure isolates (V1, V2, V3, V4, V4', V5) were obtained from the ethyl acetate extracts of the leaves of Vitex parviflora, by gravity column chromatography. Analysis of the 1H NMR, IR, and UV spectra indicated that the isolates are mixtures of compounds. V4' is a mixture of stigmasterol and sitosterol in a 1:3 ratio, V2 is a diterpene with lupeol and מּ-amyrin as minor impurities and V3 is a triacylglycerol and fatty acid mixture.

The antimutagenicity potential of V2 and V4' were tested using the micronucleus test. Results of the study indicated that V2 reduced the number of micronucleated polychromatic erythrocyte (MPCE) induced by Mitomycin-C by 60.0% while V4' reduced the MPCE by 63.2%. Thus, the isolates are antimutagens.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU17496

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

iv, 66 leaves: illustrations; 28 cm.

Keywords

Ethyl acetoacetate

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