Title

Antimutagenicity potential of isolates from the Dichloromethane extract of Solanum nigrum

Date of Publication

1997

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Consolacion Ragasa

Defense Panel Chair

Gerardo Janairo

Abstract/Summary

The leaves of Solanum nigrum were air dried, ground and soaked in dichloromethane. The dichloromethane extract afforded three isolates which were obtained by repeated gravity column chromatography, and monitored by thin layer chromatography. The three isolates were tested for antimutagenicity potential by the Micronucleus test. Results showed that TLC pure isolate A increased the number of micronucleated polychromatic erythrocytes (MPCE) induced by Mitomycin C by 34.87%. Thus, it is a mutagen. On the other hand, TLC pure isolates B and C reduced the number of MPCE by 11.58% and 67.50% respectively. Thus, both compounds are antimutagens.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU17469

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

[7], 49 leaves : illustrations (some color) ; 28 cm.

Keywords

Antimutagens; Dichloromethane; Methane; Solanum nigrum

This document is currently not available here.

Share

COinS