Title

Isolation and structural elucidation of the chemical constituents of terminalia foetidissima leaves

Date of Publication

2018

Document Type

Bachelor's Thesis

Degree Name

Bachelor of Science in Biochemistry

Subject Categories

Chemistry

College

College of Science

Department/Unit

Chemistry

Thesis Adviser

Vincent Antonio Ng

Defense Panel Member

Consolacion Y. Ragasa
Jan-Michael C. Cayme
Jaime Raul O. Janairo

Abstract/Summary

Terminalia foetidissima, locally known as talisay gubat, is a native plant in the Philippines and is found to have antioxidant and cytotoxic properties. The leaves were obtained from Mt. Makiling, Laguna, Philippines. It was air dried for two weeks, ground with a blender and soaked in dicholoromethane for three days. The extract was concentrated in vacuum and was subjected to a normal-phased open column chromatography under DCM-acetone fraction with an increasing 10% v/v. The samples were then concentrated in vacuum and re-chromatographed. The purity was monitored using thin layer chromatography. Those with similar profile was combined and was re-chromatographed until TLC pure. Ten TLC pure isolated samples were then subjected to 600 MHz 1d ¹H nuclear magnetic resonance (NMR). It was determined that the isolated compounds are hydrocarbon, squalene, cyloeucalenol, and a mixture of 3-epicycloeucalenol, stigmaterol, and β-sitosterol. This is the first chemical study on the plant.

Abstract Format

html

Language

English

Format

Print

Accession Number

TU17345

Shelf Location

Archives, The Learning Commons, 12F, Henry Sy Sr. Hall

Physical Description

48 leaves ; illustrations (some color) ; 28 cm.

Keywords

Medicinal plants--Philippines; Terminalia foetidissima; Talisay gubat

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